Footage shows a fire on the upper floors of the former Pennine Hotel on Macklin Street in Derby.
The building is disused and partially demolished, Derbyshire Police said.
A Derbyshire Fire and Rescue Service first received a call about the blaze at 8.52pm on Saturday May 28, a spokesperson said.
The spokesperson confirmed that eight fire engines and two aerial ladder platforms had been dispatched to the scene.
Nottinghamshire fire crews were also called for help, Derbyshire Live reported.
A number of roads have been closed in the city center as emergency crews travel to the scene.
A cordon would be in place around Colyear Street.
The Derbyshire Fire and Rescue Service has asked the public to avoid the area.
They tweeted: ‘Fire crews are currently battling a fire at the former Pennine Hotel on Macklin Street in #Derby. Please avoid the area. »
Derbyshire Police released a statement about the incident.
It read: ‘We have closed a number of roads in Derby town center after a fire broke out in a disused and partially demolished hotel.
“The fire started in buildings on the site of the former Pennine Hotel earlier this evening.
“Police and firefighters are at the scene and several roads in the immediate vicinity are closed.
“We are also advising residents of the city to stay indoors and keep windows and doors closed due to the risk of smoke spreading.”
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